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Restylane Defyne

A strong and flexible filler for
deeper facial folds

What is Restylane Defyne?

Restylane Defyne is one of many products in the Restylane family of hyaluronic acid-based dermal fillers.

Restylane Defyne is an FDA-approved dermal filler for deep, moderate-to-severe nasolabial folds and marionette lines. In other words, it’s specially formulated for adding volume to significant, deep wrinkles like laugh lines or droopy lower face structures.

How does Restylane Defyne differ
from other Restylane products?

Restylane and Restylane Defyne are both hyaluronic acid fillers in the Restylane product line.

Restylane Defyne differs from other Restylane products in the cross-linking of its hyaluronic acid formulation. This higher-percentage cross-linking increases the filler’s density which creates a more flexible, longer-lasting solution where it’s needed most –  such as the dynamic folds of the smile lines and lower face wrinkles. In short, Restylane Defyne is a sister to Restylane Refyne, but its formula is better suited for deeper, more severe facial wrinkles.

How is Restylane Defyne commonly used?

With the age-related loss of skin hydration and elasticity, deep lines may form around the corners of the nose and mouth, and these nasolabial folds and/or marionette lines become much more visible, giving the face a more tired and aged appearance.

It is generally injected in the deeper layers of the skin to reduce and soften moderate to severe folds and wrinkles. Restylane Defyne’s structural design not only gives it durability and increased longevity but also great flexibility. This flexibility makes it ideal when injected in facial areas that experience a great deal of movement, such as the smile lines.

How long do results last?

Restylane Defyne sports more durability than its sister products in the Restylane line and generally endures up to around 12 months before retreatment may be needed!

Are there side effects to be aware
of with Restylane Defyne?

According to the Restylane clinical studies, the most commonly observed side effects are swelling, redness, pain, and bruising at the injection site. These are typically quite mild, and they should dissipate within several days depending on the treatment site.

Dr. Brandish uses a smooth-tipped cannula to inject dermal fillers which significantly reduces bruising and downtime and makes the procedure much safer to administer.

More information about side effects can be found on Restylane USA’s website.

Restylane Defyne Summary

Restylane Defyne is a cross-linked hyaluronic acid-based filler with a flexible composition, making it an effective solution for restoring natural-looking and natural-feeling volume in areas of deep, pronounced skin folds. It is a very effective solution for the treatment of areas with increased movement such as the nasolabial folds and marionette lines, otherwise known as “laugh lines”. Restylane Defyne’s improved formulation allows for gorgeous, lasting results.

How do I get started?

If you’re interested in hearing more or in scheduling an appointment, contact our office at

We will be happy to take care of you. We offer free consultation appointments if you’d like to simply go over any problem areas and see if Restylane or other treatment options may be the most effective solution for you.